| Reaction Details |
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 | Report a problem with these data |
| Target | Trypsin-1 |
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| Ligand | BDBM50111729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212857 |
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| Ki | 4.4±n/a nM |
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| Citation |  Reiner JE; Siev DV; Araldi GL; Cui JJ; Ho JZ; Reddy KM; Mamedova L; Vu PH; Lee KS; Minami NK; Gibson TS; Anderson SM; Bradbury AE; Nolan TG; Semple JE Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. Bioorg Med Chem Lett 12:1203-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypsin-1 |
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| Name: | Trypsin-1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | Trypsin | Trypsin I |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50111729 |
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| n/a |
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| Name | BDBM50111729 |
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| Synonyms: | CHEMBL277695 | N-(5-Carbamimidoyl-thiophen-2-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N6O2S |
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| Mol. Mass. | 424.519 |
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| SMILES | Cc1cnc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc(s1)C(N)=N |
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| Structure | 
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