| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50111955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_49330 (CHEMBL660847) |
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| Ki | 10±n/a nM |
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| Citation |  He, W; Hanney, B; Myers, MR; Condon, S; Becker, MR; Spada, AP; Burns, C; Brown, K; Colussi, D; Chu, V Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors. Bioorg Med Chem Lett12:919-22 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50111955 |
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| n/a |
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| Name | BDBM50111955 |
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| Synonyms: | 1-(4-Amino-quinazolin-7-ylmethyl)-4-(6-chloro-1H-benzoimidazol-2-ylmethyl)-piperazin-2-one | CHEMBL354996 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20ClN7O |
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| Mol. Mass. | 421.883 |
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| SMILES | Nc1ncnc2cc(CN3CCN(Cc4nc5ccc(Cl)cc5[nH]4)CC3=O)ccc12 |
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| Structure | 
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