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TargetHistamine H3 receptor
LigandBDBM50112021
Substrate/Competitorn/a
Meas. Tech.ChEBML_85849
Ki 7±n/a nM
Citation Aslanian, RMutahi, MWShih, NYMcCormick, KDPiwinski, JJTing, PCAlbanese, MMBerlin, MYZhu, XWong, SCRosenblum, SBJiang, YWest, RShe, SWilliams, SMBryant, MHey, JA Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template. Bioorg Med Chem Lett12:937-41 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:48753.61
Organism:GUINEA PIG
Description:HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50112021
n/a
NameBDBM50112021
Synonyms:1-(3,4-Dichloro-phenyl)-3-[4-(1H-imidazol-4-ylmethyl)-benzyl]-urea | CHEMBL435728
TypeSmall organic molecule
Emp. Form.C18H16Cl2N4O
Mol. Mass.375.252
SMILESClc1ccc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)cc1Cl
Structure
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