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TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
LigandBDBM50112376
Substrate/Competitorn/a
Meas. Tech.ChEMBL_70146 (CHEMBL685969)
IC50 159±n/a nM
Citation Nguyen, DNStump, CAWalsh, ESFernandes, CDavide, JPEllis-Hutchings, MRobinson, RGWilliams, TMLobell, RBHuber, HEBuser, CA Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I. Bioorg Med Chem Lett12:1269-73 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Name:Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:Protein Farnesyltransferase (PFT) | Protein farnesyltransferase
Type:Protein Complex
Mol. Mass.:n/a
Description:Purified bovine brain FTase.
Components:This complex has 2 components.
Component 1
Name:Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:CAAX farnesyltransferase alpha subunit | FNTA | FNTA_BOVIN | FTase-alpha | GGTase-I-alpha | Geranylgeranyl Transferase (GGTase-I) Chain A | Protein Farnesyltransferase (PFT) Chain A | Protein farnesyltransferase | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Ras proteins prenyltransferase alpha | Type I protein geranyl-geranyltransferase alpha subunit
Type:Enzyme
Mol. Mass.:43827.38
Organism:Bos taurus (bovine)
Description:The enzyme was purified from a bovine brain homogenate by sequential ammonium sulfate fractionation and affinity chromatography.
Residue:375
Sequence:
MAAADGVGEAAQGGDPGQPEPPPPPQPHPPPPPPQPPQEEAAAASPIDDGFLSLDSPTYV
LYRDRPEWADIDPVPQNDGPNPVVQIIYSEKFQDVYDYFRAVLQRDERSERAFKLTRDAI
ELNAANYTVWHFRRVLLKSLQKDLHEEMNYISAIIEEQPKNYQVWHHRRVLVEWLRDPSQ
ELEFIADILTQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVI
SNTTGYNDRAILEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQP
SHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQ
SKHSTESDPPTNVQQ
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Component 2
Name:Protein farnesyltransferase subunit beta
Synonyms:CAAX farnesyltransferase subunit beta | FNTB | FNTB_BOVIN | FTase-beta | Protein farnesyltransferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | RAS proteins prenyltransferase beta | Ras proteins prenyltransferase subunit beta
Type:Enzyme Subunit
Mol. Mass.:48758.49
Organism:Bos taurus (bovine)
Description:Protein farnesyltransferase subunit beta
Residue:437
Sequence:
MASPSSFTYCCPPSSSPIWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
MVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDVINREKLLQY
LYSLKQPDGSFLMHDGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSRWMFHQQALQEYILMCCQCPTGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATMHFLQKPV
PGFEEHEDEASAEPATD
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BDBM50112376
n/a
NameBDBM50112376
Synonyms:1-(3-Chloro-phenyl)-4-{3-[6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethyl]-3H-imidazol-4-ylmethyl}-piperazin-2-one | CHEMBL23163
TypeSmall organic molecule
Emp. Form.C27H23ClF3N5O
Mol. Mass.525.953
SMILESFC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cn1
Structure
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