Ki Summary

Reaction Details

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Target

Coagulation factor X

Ligand

BDBM50112488

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_49302

0.270000±n/a nM

Citation

Wu, S; Guilford, WJ; Chou, YL; Griedel, BD; Liang, A; Sakata, S; Shaw, KJ; Trinh, L; Xu, W; Zhao, Z; Morrissey, MM Design and synthesis of aminophenol-based factor Xa inhibitors. Bioorg Med Chem Lett12:1307-10 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Coagulation factor X

Name:

Coagulation factor X

Synonyms:

Type:

Enzyme

Mol. Mass.:

54726.60

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

488

Sequence:

MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK

BDBM50112488

n/a

Name

BDBM50112488

Synonyms:

3-(3-{4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-nitro-phenylamino}-propenyl)-benzamidine | CHEMBL24630

Type

Small organic molecule

Emp. Form.

C23H28N6O3

Mol. Mass.

436.5068

SMILES

CC([NH-])=[N+]1CCC(CC1)Oc1ccc(NC\C=C\c2cccc(c2)C(N)=N)cc1[N+]([O-])=O |(-5.78,-2.46,;-4.43,-3.23,;-4.45,-4.77,;-3.1,-2.46,;-3.1,-.92,;-1.77,-.16,;-.44,-.94,;-.44,-2.47,;-1.77,-3.24,;.91,-.17,;2.24,-.94,;2.24,-2.48,;3.57,-3.25,;4.91,-2.48,;6.24,-3.25,;6.24,-4.79,;7.58,-5.56,;7.57,-7.1,;8.9,-7.87,;8.91,-9.41,;10.25,-10.18,;11.58,-9.4,;11.57,-7.85,;10.23,-7.09,;12.9,-7.07,;12.89,-5.53,;14.24,-7.82,;4.91,-.94,;3.57,-.17,;3.55,1.37,;4.9,2.14,;2.22,2.14,)|

Structure