Ki Summary

Reaction Details

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Target

Coagulation factor X

Ligand

BDBM50112506

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_49302

0.070000±n/a nM

Citation

Wu, S; Guilford, WJ; Chou, YL; Griedel, BD; Liang, A; Sakata, S; Shaw, KJ; Trinh, L; Xu, W; Zhao, Z; Morrissey, MM Design and synthesis of aminophenol-based factor Xa inhibitors. Bioorg Med Chem Lett12:1307-10 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Coagulation factor X

Name:

Coagulation factor X

Synonyms:

Type:

Enzyme

Mol. Mass.:

54726.60

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

488

Sequence:

MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK

BDBM50112506

n/a

Name

BDBM50112506

Synonyms:

3-(3-{4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-nitro-phenylamino}-2-methyl-propenyl)-benzamidine | CHEMBL27228

Type

Small organic molecule

Emp. Form.

C24H30N6O3

Mol. Mass.

450.5334

SMILES

C\C(CNc1ccc(OC2CC[N+](CC2)=C(C)[NH-])c(c1)[N+]([O-])=O)=C/c1cccc(c1)C(N)=N |(8.92,-4.79,;7.58,-5.56,;6.23,-4.79,;6.23,-3.25,;4.91,-2.48,;3.57,-3.25,;2.24,-2.48,;2.24,-.94,;.91,-.17,;-.44,-.94,;-1.76,-.16,;-3.09,-.92,;-3.1,-2.46,;-1.76,-3.24,;-.44,-2.47,;-4.43,-3.23,;-5.78,-2.46,;-4.45,-4.77,;3.57,-.17,;4.91,-.94,;3.55,1.37,;4.9,2.14,;2.22,2.14,;7.56,-7.1,;8.89,-7.87,;8.91,-9.41,;10.25,-10.18,;11.58,-9.4,;11.57,-7.84,;10.22,-7.09,;12.9,-7.07,;12.88,-5.53,;14.23,-7.82,)|

Structure