Reaction Details |
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Target | Methionine--tRNA ligase, cytoplasmic |
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Ligand | BDBM50112575 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105280 (CHEMBL718948) |
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IC50 | 1±n/a nM |
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Citation | Jarvest, RL; Berge, JM; Berry, V; Boyd, HF; Brown, MJ; Elder, JS; Forrest, AK; Fosberry, AP; Gentry, DR; Hibbs, MJ; Jaworski, DD; O'Hanlon, PJ; Pope, AJ; Rittenhouse, S; Sheppard, RJ; Slater-Radosti, C; Worby, A Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. J Med Chem45:1959-62 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase, cytoplasmic |
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Name: | Methionine--tRNA ligase, cytoplasmic |
Synonyms: | MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 101110.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105283 |
Residue: | 900 |
Sequence: | MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
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BDBM50112575 |
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n/a |
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Name | BDBM50112575 |
Synonyms: | 2-[3-(6,8-Dibromo-1,2,3,4-tetrahydro-quinolin-4-ylamino)-propylamino]-1H-quinolin-4-one | CHEMBL304237 |
Type | Small organic molecule |
Emp. Form. | C21H22Br2N4O |
Mol. Mass. | 506.234 |
SMILES | Oc1cc(NCCCNC2CCNc3c(Br)cc(Br)cc23)nc2ccccc12 |
Structure |
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