Reaction Details |
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Target | Tyrosine-protein kinase Lck |
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Ligand | BDBM50112920 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_221484 |
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IC50 | 9±n/a nM |
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Citation | Chen, P; Norris, D; Iwanowicz, EJ; Spergel, SH; Lin, J; Gu, HH; Shen, Z; Wityak, J; Lin, TA; Pang, S; De Fex, HF; Pitt, S; Shen, DR; Doweyko, AM; Bassolino, DA; Roberge, JY; Poss, MA; Chen, BC; Schieven, GL; Barrish, JC Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett12:1361-4 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lck |
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Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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BDBM50112920 |
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n/a |
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Name | BDBM50112920 |
Synonyms: | (2-Chloro-6-methyl-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-amine | CHEMBL283212 | N-(2-chloro-6-methylphenyl)imidazo[1,5-a]quinoxalin-4-amine |
Type | Small organic molecule |
Emp. Form. | C17H13ClN4 |
Mol. Mass. | 308.765 |
SMILES | Cc1cccc(Cl)c1Nc1nc2ccccc2n2cncc12 |
Structure |
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