| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interstitial collagenase |
|---|
| Ligand | BDBM50113029 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_105983 |
|---|
| IC50 | 8.5±n/a nM |
|---|
| Citation |  Letavic, MA; Axt, MZ; Barberia, JT; Carty, TJ; Danley, DE; Geoghegan, KF; Halim, NS; Hoth, LR; Kamath, AV; Laird, ER; Lopresti-Morrow, LL; McClure, KF; Mitchell, PG; Natarajan, V; Noe, MC; Pandit, J; Reeves, L; Schulte, GK; Snow, SL; Sweeney, FJ; Tan, DH; Yu, CH Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett12:1387-90 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interstitial collagenase |
|---|
| Name: | Interstitial collagenase |
|---|
| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54010.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03956 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
|---|
| BDBM50113029 |
|---|
| n/a |
|---|
| Name | BDBM50113029 |
|---|
| Synonyms: | (2R,4R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-2-hydroxycarbamoyl-piperidine-4-carboxylic acid methyl ester | CHEMBL286772 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21FN2O7S |
|---|
| Mol. Mass. | 452.453 |
|---|
| SMILES | COC(=O)[C@@H]1CCN([C@H](C1)C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
