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TargetGeranylgeranyl pyrophosphate synthase
LigandBDBM50113285
Substrate/Competitorn/a
Meas. Tech.ChEMBL_71679 (CHEMBL681671)
IC50 370±n/a nM
Citation Szabo, CMMatsumura, YFukura, SMartin, MBSanders, JMSengupta, SCieslak, JALoftus, TCLea, CRLee, HJKoohang, ACoates, RMSagami, HOldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem45:2185-96 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl pyrophosphate synthase
Name:Geranylgeranyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (Human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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  Blast E-value cutoff:
BDBM50113285
n/a
NameBDBM50113285
Synonyms:3-[methyl-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-amino]-propyl trihydrogendiphosphate(3-aza-homoGGPP) | CHEMBL67986
TypeSmall organic molecule
Emp. Form.C20H39NO7P2
Mol. Mass.467.4737
SMILES[#6]-[#7](-[#6]-[#6]-[#6]-[#8]P([#8])(=O)[#8]P([#8])([#8])=O)-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]
Structure
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