| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM25269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71679 (CHEMBL681671) |
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| IC50 | 720±n/a nM |
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| Citation |  Szabo, CM; Matsumura, Y; Fukura, S; Martin, MB; Sanders, JM; Sengupta, S; Cieslak, JA; Loftus, TC; Lea, CR; Lee, HJ; Koohang, A; Coates, RM; Sagami, H; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem45:2185-96 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM25269 |
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| n/a |
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| Name | BDBM25269 |
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| Synonyms: | (1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEMBL54004 | bisphosphonate, 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H24O7P2 |
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| Mol. Mass. | 318.2409 |
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| SMILES | CCCCCCCCCC(O)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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