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TargetGeranylgeranyl pyrophosphate synthase
LigandBDBM50098382
Substrate/Competitorn/a
Meas. Tech.ChEMBL_71679 (CHEMBL681671)
IC50 410000±n/a nM
Citation Szabo, CMMatsumura, YFukura, SMartin, MBSanders, JMSengupta, SCieslak, JALoftus, TCLea, CRLee, HJKoohang, ACoates, RMSagami, HOldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem45:2185-96 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl pyrophosphate synthase
Name:Geranylgeranyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (Human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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  Blast E-value cutoff:
BDBM50098382
n/a
NameBDBM50098382
Synonyms:(1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid(NE58051,homorisedronate) | 1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyldiphosphonic acid | 3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium | 3-(3-hydrogen phosphonato-3-hydroxy-3-phosphonatopropyl)pyridin-1-ium | 3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate | CHEMBL293522
TypeSmall organic molecule
Emp. Form.C8H13NO7P2
Mol. Mass.297.1388
SMILESOC(CCc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure
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