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TargetCoagulation factor X
LigandBDBM50113591
Substrate/Competitorn/a
Meas. Tech.ChEMBL_69679
IC50 0.200000±n/a nM
Citation Song YClizbe LBhakta CTeng WLi WWu YJia ZJZhang PWang LDoughan BSu TKanter JWoolfrey JWong PHuang BTran KSinha UPark GReed AMalinowski JHollenbach SScarborough RMZhu BY Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors. Bioorg Med Chem Lett 12:1511-5 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50113591
n/a
NameBDBM50113591
Synonyms:(E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide | 3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL287252
TypeSmall organic molecule
Emp. Form.C23H20F2N4O3S
Mol. Mass.470.492
SMILESC\C(=C(/F)C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Structure
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