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TargetSerine protease 1
LigandBDBM50113800
Substrate/Competitorn/a
Meas. Tech.ChEMBL_212873 (CHEMBL817823)
Ki 7900±n/a nM
Citation Danilewicz, JCAbel, SMBrown, ADFish, PVHawkeswood, EHolland, SJJames, KMcElroy, ABOverington, JPowling, MJRance, DJ Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence. J Med Chem45:2432-53 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Serine protease 1
Name:Serine protease 1
Synonyms:Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:Enzyme
Mol. Mass.:26557.80
Organism:Homo sapiens (Human)
Description:P07477
Residue:247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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  Blast E-value cutoff:
BDBM50113800
n/a
NameBDBM50113800
Synonyms:CHEMBL81643 | RS-(1-Benzyl-2-{2-[2-(1-carbamimidoyl-piperidin-4-yloxy)-ethyl]-piperidin-1-yl}-2-oxo-ethylamino)-acetic acid
TypeSmall organic molecule
Emp. Form.C24H37N5O4
Mol. Mass.459.5817
SMILESNC(=N)N1CCC(CC1)OCCC1CCCCN1C(=O)[C@@H](Cc1ccccc1)NCC(O)=O
Structure
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