| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50114240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_124642 |
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| IC50 | 38±n/a nM |
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| Citation |  Dumas, J; Hatoum-Mokdad, H; Sibley, RN; Smith, RA; Scott, WJ; Khire, U; Lee, W; Wood, J; Wolanin, D; Cooley, J; Bankston, D; Redman, AM; Schoenleber, R; Caringal, Y; Gunn, D; Romero, R; Osterhout, M; Paulsen, H; Housley, TJ; Wilhelm, SM; Pirro, J; Chien, DS; Ranges, GE; Shrikhande, A; Muzsi, A; Bortolon, E; Wakefield, J; Gianpaolo Ostravage, C; Bhargava, A; Chau, T Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor. Bioorg Med Chem Lett12:1559-62 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50114240 |
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| n/a |
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| Name | BDBM50114240 |
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| Synonyms: | CHEMBL290982 | N-(4-{4-[3-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-ureido]-benzyl}-phenyl)-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N5O2 |
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| Mol. Mass. | 433.5459 |
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| SMILES | CCC(=O)Nc1ccc(Cc2ccc(NC(=O)Nc3cc(nn3C)C(C)(C)C)cc2)cc1 |
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| Structure | 
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