| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50114460 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_48983 |
|---|
| IC50 | 49±n/a nM |
|---|
| Citation |  Zhang, P; Zuckett, JF; Woolfrey, J; Tran, K; Huang, B; Wong, P; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors. Bioorg Med Chem Lett12:1657-61 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50114460 |
|---|
| n/a |
|---|
| Name | BDBM50114460 |
|---|
| Synonyms: | 4-(3-Carbamimidoyl-phenoxy)-3-[(2'-sulfamoyl-biphenyl-4-carbonyl)-amino]-benzoic acid | CHEMBL295128 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H22N4O6S |
|---|
| Mol. Mass. | 530.552 |
|---|
| SMILES | NC(=N)c1cccc(Oc2ccc(cc2NC(=O)c2ccc(cc2)-c2ccccc2S(N)(=O)=O)C(O)=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
