Reaction Details |
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Target | Melatonin receptor type 1B |
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Ligand | BDBM50114720 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105263 (CHEMBL715855) |
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Ki | 0.21±n/a nM |
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Citation | Wallez, V; Durieux-Poissonnier, S; Chavatte, P; Boutin, JA; Audinot, V; Nicolas, JP; Bennejean, C; Delagrange, P; Renard, P; Lesieur, D Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands. J Med Chem45:2788-800 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1B |
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Name: | Melatonin receptor type 1B |
Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
Type: | Enzyme |
Mol. Mass.: | 40203.54 |
Organism: | Homo sapiens (Human) |
Description: | P49286 |
Residue: | 362 |
Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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BDBM50114720 |
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n/a |
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Name | BDBM50114720 |
Synonyms: | But-2-enoic acid [2-(5-methoxy-2-phenyl-benzofuran-3-yl)-ethyl]-amide | CHEMBL96104 |
Type | Small organic molecule |
Emp. Form. | C21H21NO3 |
Mol. Mass. | 335.3963 |
SMILES | COc1ccc2oc(c(CCNC(=O)\C=C\C)c2c1)-c1ccccc1 |
Structure |
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