| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50104929 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_49996 (CHEMBL661336) |
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| Ki | 25±n/a nM |
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| Citation |  Palani, A; Shapiro, S; Josien, H; Bara, T; Clader, JW; Greenlee, WJ; Cox, K; Strizki, JM; Baroudy, BM Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity. J Med Chem45:3143-60 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | CC-CKR-5 | CCR-5 | CCR5_MOUSE | CD_antigen=CD195 | Ccr5 | Cmkbr5 | MIP-1 alpha receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40803.93 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_49996 |
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| Residue: | 354 |
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| Sequence: | MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISC
KKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFF
IILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTC
SPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIF
AIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYA
FVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL
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| BDBM50104929 |
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| n/a |
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| Name | BDBM50104929 |
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| Synonyms: | (4-{(4-Bromo-phenyl)-[(E)-methoxyimino]-methyl}-4'-methyl-[1,4']bipiperidinyl-1'-yl)-(2,6-dimethyl-phenyl)-methanone | (E)-{4-[(4-Bromo-phenyl)-methoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,6-dimethyl-phenyl)-methanone | (E/Z)-{4-[(4-Bromo-phenyl)-methoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,6-dimethyl-phenyl)-methanone | CHEMBL112760 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36BrN3O2 |
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| Mol. Mass. | 526.508 |
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| SMILES | CO\N=C(/C1CCN(CC1)C1(C)CCN(CC1)C(=O)c1c(C)cccc1C)c1ccc(Br)cc1 |
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| Structure | 
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