| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM18884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210502 (CHEMBL811897) |
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| Kd | 35±n/a nM |
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| Citation |  Nguyen, NH; Apriletti, JW; Cunha Lima, ST; Webb, P; Baxter, JD; Scanlan, TS Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem45:3310-20 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM18884 |
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| n/a |
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| Name | BDBM18884 |
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| Synonyms: | 2-(4-{[4-hydroxy-3-(4-nitrophenyl)-5-(propan-2-yl)phenyl]methyl}-3,5-dimethylphenoxy)acetic acid | CHEMBL112087 | JMC496635 Compound 4 | thyromimetic, 5a |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27NO6 |
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| Mol. Mass. | 449.4957 |
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| SMILES | CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(c1O)-c1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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