Reaction Details |
| Report a problem with these data |
Target | Thyroid hormone receptor beta |
---|
Ligand | BDBM50115667 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_210499 (CHEMBL811714) |
---|
EC50 | 500±n/a nM |
---|
Citation | Nguyen, NH; Apriletti, JW; Cunha Lima, ST; Webb, P; Baxter, JD; Scanlan, TS Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem45:3310-20 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thyroid hormone receptor beta |
---|
Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
|
|
|
BDBM50115667 |
---|
n/a |
---|
Name | BDBM50115667 |
Synonyms: | CHEMBL111953 | [4-(4-Hydroxy-3-isopropyl-5-phenylethynyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid(NH-1) |
Type | Small organic molecule |
Emp. Form. | C28H28O4 |
Mol. Mass. | 428.5195 |
SMILES | CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccccc2)c1O |
Structure |
|