| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
|---|
| Ligand | BDBM21653 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_64199 |
|---|
| Ki | 26±n/a nM |
|---|
| Citation |  Inguimbert, N; Poras, H; Teffo, F; Beslot, F; Selkti, M; Tomas, A; Scalbert, E; Bennejean, C; Renard, P; Fournié-Zaluski, MC; Roques, BP N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities. Bioorg Med Chem Lett12:2001-5 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-converting enzyme 1 |
|---|
| Name: | Endothelin-converting enzyme 1 |
|---|
| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 87155.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42892 |
|---|
| Residue: | 770 |
|---|
| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
|
|
|
|---|
| BDBM21653 |
|---|
| n/a |
|---|
| Name | BDBM21653 |
|---|
| Synonyms: | (2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid | CHEMBL285490 | Mercaptoacyl amino acid compound, 13b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N2O3S |
|---|
| Mol. Mass. | 408.513 |
|---|
| SMILES | OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)[C@H]1CCc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
