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TargetCoagulation factor X
LigandBDBM50115933
Substrate/Competitorn/a
Meas. Tech.ChEMBL_48991
Ki 1.1±n/a nM
Citation Song YClizbe LBhakta CTeng WLi WWong PHuang BSinha UPark GReed AScarborough RMZhu BY Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification. Bioorg Med Chem Lett 12:2043-6 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50115933
n/a
NameBDBM50115933
Synonyms:(E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL63041
TypeSmall organic molecule
Emp. Form.C25H20ClFN4O3S
Mol. Mass.510.968
SMILESC\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1
Structure
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