| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50115933 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48991 (CHEMBL872478) |
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| Ki | 1.1±n/a nM |
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| Citation |  Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification. Bioorg Med Chem Lett12:2043-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50115933 |
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| n/a |
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| Name | BDBM50115933 |
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| Synonyms: | (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL63041 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20ClFN4O3S |
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| Mol. Mass. | 510.968 |
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| SMILES | C\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 |
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| Structure | 
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