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TargetSubstance-P receptor
LigandBDBM50115965
Substrate/Competitorn/a
Meas. Tech.ChEBML_205391
IC50 1±n/a nM
Citation Mah RGerspacher Mvon Sprecher AStutz STschinke VAnderson GPBertrand CSubramanian NBall HA Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists. Bioorg Med Chem Lett 12:2065-8 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Substance-P receptor
Name:Neurokinin 1 receptor
Synonyms:NK-1 receptor | NK-1R | NK1 Receptor | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46254.43
Organism:Homo sapiens (Human)
Description:P25103
Residue:407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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  Blast E-value cutoff:
BDBM50115965
n/a
NameBDBM50115965
Synonyms:2-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]-4'-chloro-biphenyl-4-carboxylic acid (3-dimethylamino-propyl)-amide | CHEMBL62679
TypeSmall organic molecule
Emp. Form.C28H26ClF6N3O2
Mol. Mass.585.968
SMILESCN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(c1)N(C)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure
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