| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50116033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_124498 |
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| IC50 | 800±n/a nM |
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| Citation |  Revesz, L; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Wolf, R; Zimmerlin, AG SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors. Bioorg Med Chem Lett12:2109-12 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 41281.22 |
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| Organism: | Mus musculus (mouse) |
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| Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50116033 |
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| n/a |
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| Name | BDBM50116033 |
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| Synonyms: | 2-(4-Fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole | 4-[2-(4-Fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine | CHEMBL66802 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11FN2 |
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| Mol. Mass. | 238.2596 |
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| SMILES | Fc1ccc(cc1)-c1[nH]ccc1-c1ccncc1 |
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| Structure | 
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