Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50116104 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_51124 | ||
Ki | 3±n/a nM | ||
Citation | Yuan, J; Gulianello, M; De Lombaert, S; Brodbeck, R; Kieltyka, A; Hodgetts, KJ 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett12:2133-6 (2002) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50116104 | |||
n/a | |||
Name | BDBM50116104 | ||
Synonyms: | CHEMBL66275 | [2,5-Dimethyl-3-(2,4,6-trimethyl-phenyl)-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-dipropyl-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C22H31N5 | ||
Mol. Mass. | 365.515 | ||
SMILES | CCCN(CCC)c1nc(C)nc2c(-c3c(C)cc(C)cc3C)n(C)nc12 |(-4.13,3.59,;-2.82,2.79,;-2.84,1.25,;-1.53,.44,;-.18,1.19,;-.14,2.73,;1.2,3.47,;-1.56,-1.1,;-2.91,-1.83,;-2.94,-3.37,;-4.28,-4.11,;-1.63,-4.18,;-.27,-3.43,;1.2,-3.93,;1.64,-5.4,;3.13,-5.74,;4.18,-4.6,;3.6,-7.21,;2.54,-8.34,;2.99,-9.81,;1.03,-7.99,;.59,-6.52,;-.9,-6.17,;2.13,-2.69,;3.67,-2.73,;1.24,-1.43,;-.23,-1.89,)| | ||
Structure |