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TargetCorticotropin releasing factor receptor 1
LigandBDBM50116109
Substrate/Competitorn/a
Meas. Tech.ChEBML_51124
Ki 4±n/a nM
Citation Yuan JGulianello MDe Lombaert SBrodbeck RKieltyka AHodgetts KJ 3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists. Bioorg Med Chem Lett 12:2133-6 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Corticotropin releasing factor receptor 1
Name:Corticotropin releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50116109
n/a
NameBDBM50116109
Synonyms:CHEMBL302742 | [3-(4-Chloro-2-methyl-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-dipropyl-amine
TypeSmall organic molecule
Emp. Form.C20H26ClN5
Mol. Mass.371.907
SMILESCCCN(CCC)c1nc(C)nc2c(-c3ccc(Cl)cc3C)n(C)nc12 |(1.59,4.49,;.26,3.72,;.28,2.18,;-1.06,1.41,;-2.39,2.17,;-2.39,3.7,;-3.73,4.47,;-1.05,-.12,;-2.38,-.91,;-2.38,-2.45,;-3.72,-3.21,;-1.05,-3.21,;.29,-2.45,;1.76,-2.92,;2.24,-4.39,;1.2,-5.52,;1.68,-6.99,;3.18,-7.3,;3.66,-8.77,;4.2,-6.15,;3.74,-4.69,;4.75,-3.55,;2.66,-1.66,;4.2,-1.66,;1.76,-.4,;.29,-.89,)|
Structure
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