| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50067485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71448 (CHEMBL684347) |
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| IC50 | 0.200000±n/a nM |
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| Citation |  Wilcoxen, KM; Zhu, YF; Connors, PJ; Saunders, J; Gross, TD; Gao, Y; Reinhart, GJ; Struthers, RS; Chen, C Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. Bioorg Med Chem Lett12:2179-83 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50067485 |
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| n/a |
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| Name | BDBM50067485 |
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| Synonyms: | 3-[(Benzyl-methyl-amino)-methyl]-7-(2,6-difluoro-benzyl)-2-(4-isobutyrylamino-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid isopropyl ester; hydrochloride | CHEMBL544440 | CHEMBL71917 | T-98475 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H37F2N3O4S |
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| Mol. Mass. | 657.769 |
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| SMILES | CC(C)OC(=O)c1cn(Cc2c(F)cccc2F)c2sc(c(CN(C)Cc3ccccc3)c2c1=O)-c1ccc(NC(=O)C(C)C)cc1 |
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| Structure | 
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