| Reaction Details |
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 | Report a problem with these data |
| Target | Granzyme B |
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| Ligand | BDBM50116257 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72172 |
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| Ki | 270±n/a nM |
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| Citation |  Willoughby, CA; Bull, HG; Garcia-Calvo, M; Jiang, J; Chapman, KT; Thornberry, NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett12:2197-200 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Granzyme B |
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| Name: | Granzyme B |
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| Synonyms: | CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27735.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_469245 |
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| Residue: | 247 |
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| Sequence: | MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
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| BDBM50116257 |
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| n/a |
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| Name | BDBM50116257 |
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| Synonyms: | 3-[((S)-{1-[(S)-2-((3S,4S)-2-Acetylamino-3-methyl-pentanoylamino)-acetyl]-pyrrolidin-2-yl}-oxo-methyl)-amino]-4-oxo-butyric acid | CHEMBL69424 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H30N4O7 |
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| Mol. Mass. | 426.4641 |
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| SMILES | CC[C@H](C)[C@H](NC(C)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C=O |
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| Structure | 
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