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TargetGranzyme B
LigandBDBM50116262
Substrate/Competitorn/a
Meas. Tech.ChEBML_72172
Ki 7±n/a nM
Citation Willoughby CABull HGGarcia-Calvo MJiang JChapman KTThornberry NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett 12:2197-200 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Granzyme B
Name:Granzyme B
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:27735.56
Organism:Homo sapiens (Human)
Description:ChEMBL_469245
Residue:247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
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  Blast E-value cutoff:
BDBM50116262
n/a
NameBDBM50116262
Synonyms:(2S,5S)-5-[(S)-2-(2-Benzo[b]thiophen-3-yl-acetylamino)-3-(S)-methyl-pentanoylamino]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid (1H-pyrazol-4-ylmethyl)-amide | CHEMBL306860
TypeSmall organic molecule
Emp. Form.C33H36N6O4S
Mol. Mass.612.742
SMILESCC[C@H](C)[C@H](NC(=O)Cc1csc2ccccc12)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1cn[nH]c1
Structure
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