| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Granzyme B |
|---|
| Ligand | BDBM50116263 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_72172 |
|---|
| Ki | 122±n/a nM |
|---|
| Citation |  Willoughby, CA; Bull, HG; Garcia-Calvo, M; Jiang, J; Chapman, KT; Thornberry, NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett12:2197-200 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Granzyme B |
|---|
| Name: | Granzyme B |
|---|
| Synonyms: | CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27735.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_469245 |
|---|
| Residue: | 247 |
|---|
| Sequence: | MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
|
|
|
|---|
| BDBM50116263 |
|---|
| n/a |
|---|
| Name | BDBM50116263 |
|---|
| Synonyms: | (S)-3-{[(S)-(5S,7S)-6-((3S,4S)-2-Acetylamino-3-methyl-pentanoylamino)-5-oxo-octahydro-indolizine-3-carbonyl]-amino}-4-oxo-butyric acid | CHEMBL71937 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H32N4O7 |
|---|
| Mol. Mass. | 452.5014 |
|---|
| SMILES | CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@H]1CC[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H](CC(O)=O)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
