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TargetGranzyme B
LigandBDBM50116263
Substrate/Competitorn/a
Meas. Tech.ChEBML_72172
Ki 122±n/a nM
Citation Willoughby CABull HGGarcia-Calvo MJiang JChapman KTThornberry NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett 12:2197-200 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Granzyme B
Name:Granzyme B
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:27735.56
Organism:Homo sapiens (Human)
Description:ChEMBL_469245
Residue:247
Sequence:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
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  Blast E-value cutoff:
BDBM50116263
n/a
NameBDBM50116263
Synonyms:(S)-3-{[(S)-(5S,7S)-6-((3S,4S)-2-Acetylamino-3-methyl-pentanoylamino)-5-oxo-octahydro-indolizine-3-carbonyl]-amino}-4-oxo-butyric acid | CHEMBL71937
TypeSmall organic molecule
Emp. Form.C21H32N4O7
Mol. Mass.452.5014
SMILESCC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@H]1CC[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H](CC(O)=O)C=O
Structure
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