| Reaction Details |
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 | Report a problem with these data |
| Target | Granzyme B |
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| Ligand | BDBM50116265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72172 |
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| Ki | 85±n/a nM |
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| Citation |  Willoughby, CA; Bull, HG; Garcia-Calvo, M; Jiang, J; Chapman, KT; Thornberry, NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett12:2197-200 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Granzyme B |
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| Name: | Granzyme B |
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| Synonyms: | CGL1 | CSPB | CTLA1 | GRAB_HUMAN | GRB | GZMB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27735.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_469245 |
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| Residue: | 247 |
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| Sequence: | MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
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| BDBM50116265 |
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| n/a |
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| Name | BDBM50116265 |
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| Synonyms: | (S)-3-({(S)-(S)-5-[(S)-2-((S)-Acetyl-methyl-amino)-3-methyl-pentanoylamino]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carbonyl}-amino)-4-benzothiazol-2-yl-4-oxo-butyric acid | CHEMBL69027 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H37N5O7S |
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| Mol. Mass. | 647.741 |
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| SMILES | CC[C@H](C)[C@H](N(C)C(C)=O)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)N[C@@H](CC(O)=O)C(=O)c1nc2ccccc2s1 |
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| Structure | 
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