| Reaction Details |
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 | Report a problem with these data |
| Target | Granzyme B |
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| Ligand | BDBM50116269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72172 |
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| Ki | 74±n/a nM |
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| Citation |  Willoughby CA; Bull HG; Garcia-Calvo M; Jiang J; Chapman KT; Thornberry NA Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett 12:2197-200 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Granzyme B |
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| Name: | Granzyme B |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27735.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_469245 |
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| Residue: | 247 |
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| Sequence: | MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
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| BDBM50116269 |
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| n/a |
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| Name | BDBM50116269 |
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| Synonyms: | (2S,5S)-5-[(S)-2-(Acetyl-methyl-amino)-3-(S)-methyl-pentanoylamino]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indole-2-carboxylic acid (2H-tetrazol-5-ylmethyl)-amide | CHEMBL303944 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N8O4 |
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| Mol. Mass. | 496.5621 |
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| SMILES | CC[C@H](C)[C@H](N(C)C(C)=O)C(=O)N[C@H]1CCc2cccc3C[C@H](N(c23)C1=O)C(=O)NCc1nnn[nH]1 |
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| Structure | 
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