| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50116398 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_221318 (CHEMBL841208) |
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| IC50 | 380±n/a nM |
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| Citation |  Snow, RJ; Cardozo, MG; Morwick, TM; Busacca, CA; Dong, Y; Eckner, RJ; Jacober, S; Jakes, S; Kapadia, S; Lukas, S; Panzenbeck, M; Peet, GW; Peterson, JD; Prokopowicz, AS; Sellati, R; Tolbert, RM; Tschantz, MA; Moss, N Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. J Med Chem45:3394-405 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50116398 |
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| n/a |
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| Name | BDBM50116398 |
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| Synonyms: | 2-(2,6-Dichloro-phenylamino)-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one | CHEMBL325282 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12Cl2N4O |
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| Mol. Mass. | 347.199 |
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| SMILES | Clc1cccc(Cl)c1Nc1nc2ccc3CCNC(=O)c3c2[nH]1 |
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| Structure | 
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