| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50116721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209564 |
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| Ki | 0.600000±n/a nM |
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| Citation |  Reichard, GA; Grice, CA; Shih, NY; Spitler, J; Majmundar, S; Wang, SD; Paliwal, S; Anthes, JC; Piwinski, JJ Preparation of oxime dual NK(1)/NK(2) antagonists with reduced NK(3) affinity. Bioorg Med Chem Lett12:2355-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52221.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29371 |
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| Residue: | 465 |
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| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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| BDBM50116721 |
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| n/a |
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| Name | BDBM50116721 |
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| Synonyms: | 3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-[4-(3-isopropyl-2-oxo-tetrahydro-pyrimidin-1-yl)-piperidin-1-yl]-2-[(Z)-methoxyimino]-pentyl}-N-methyl-benzamide | CHEMBL76437 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41Cl4N5O3 |
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| Mol. Mass. | 685.512 |
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| SMILES | CO\N=C(/CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(CC1)N1CCCN(C(C)C)C1=O)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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