| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50116764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_155614 |
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| IC50 | 300±n/a nM |
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| Citation |  Wang, S; Golec, J; Miller, W; Milutinovic, S; Folkes, A; Williams, S; Brooks, T; Hardman, K; Charlton, P; Wren, S; Spencer, J Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines. Bioorg Med Chem Lett12:2367-70 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50116764 |
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| n/a |
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| Name | BDBM50116764 |
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| Synonyms: | 3-[1-Pyridin-2-yl-meth-(Z)-ylidene]-6-[1-[4-(3-pyridin-3-yl-propoxy)-phenyl]-meth-(Z)-ylidene]-piperazine-2,5-dione | CHEMBL77246 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N4O3 |
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| Mol. Mass. | 426.4672 |
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| SMILES | O=c1[nH]\c(=C/c2ccccn2)c(=O)[nH]\c1=C/c1ccc(OCCCc2cccnc2)cc1 |
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| Structure | 
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