| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50116915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_79956 |
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| IC50 | 0.230000±n/a nM |
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| Citation |  Cheng, Y; Zhang, F; Rano, TA; Lu, Z; Schleif, WA; Gabryelski, L; Olsen, DB; Stahlhut, M; Rutkowski, CA; Lin, JH; Jin, L; Emini, EA; Chapman, KT; Tata, JR Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains. Bioorg Med Chem Lett12:2419-22 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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| BDBM50116915 |
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| n/a |
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| Name | BDBM50116915 |
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| Synonyms: | (S)-4-Furo[3,2-c]pyridin-2-ylmethyl-1-[(2S,4R)-2-hydroxy-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide | CHEMBL81840 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H47N5O5 |
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| Mol. Mass. | 653.8103 |
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| SMILES | CC(C)(C)NC(=O)[C@@H]1CN(Cc2cc3cnccc3o2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |
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| Structure | 
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