Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_79956 |
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IC50 | 0.590000±n/a nM |
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Citation | Cheng, Y; Zhang, F; Rano, TA; Lu, Z; Schleif, WA; Gabryelski, L; Olsen, DB; Stahlhut, M; Rutkowski, CA; Lin, JH; Jin, L; Emini, EA; Chapman, KT; Tata, JR Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains. Bioorg Med Chem Lett12:2419-22 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM517 |
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n/a |
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Name | BDBM517 |
Synonyms: | (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide | CHEMBL115 | Crixivan | INDINAVIR SULFATE | Indinavir | Indinavir, 19 | L-735, 524 | MK639 |
Type | Small organic molecule |
Emp. Form. | C36H47N5O4 |
Mol. Mass. | 613.7895 |
SMILES | CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |@:19,@@:9| |
Structure |
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