Reaction Details |
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Target | Mycothiol S-conjugate amidase |
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Ligand | BDBM50117085 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_140808 |
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IC50 | 450000±n/a nM |
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Citation | Nicholas, GM; Eckman, LL; Ray, S; Hughes, RO; Pfefferkorn, JA; Barluenga, S; Nicolaou, KC; Bewley, CA Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg Med Chem Lett12:2487-90 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mycothiol S-conjugate amidase |
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Name: | Mycothiol S-conjugate amidase |
Synonyms: | MCA_MYCTU | mca |
Type: | PROTEIN |
Mol. Mass.: | 32719.79 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_626858 |
Residue: | 288 |
Sequence: | MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERGEILNPAMDLPDVHGR
IAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDDCFARVPLEVSTEALVRVV
REFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFCRFPDAGEPWTVSKLYYVHGF
LRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSRVTTRVECSKYFSQRDDALRAHA
TQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPARPPETELFAGIEP
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BDBM50117085 |
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n/a |
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Name | BDBM50117085 |
Synonyms: | CHEMBL81748 | N-[2-(4-Amino-phenyldisulfanyl)-ethyl]-3-(3,5-difluoro-phenyl)-2-[(Z)-hydroxyimino]-propionamide |
Type | Small organic molecule |
Emp. Form. | C17H17F2N3O2S2 |
Mol. Mass. | 397.463 |
SMILES | Nc1ccc(SSCCNC(=O)C(Cc2cc(F)cc(F)c2)N=O)cc1 |
Structure |
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