Reaction Details |
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Target | P04972/P11541/P16586/P22571/P23439/Q95142 |
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Ligand | BDBM50117715 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155385 (CHEMBL760838) |
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IC50 | 6±n/a nM |
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Citation | Arnold, R; Beer, D; Bhalay, G; Baettig, U; Collingwood, SP; Craig, S; Devereux, N; Dunstan, A; Glen, A; Gomez, S; Haberthuer, S; Howe, T; Jelfs, S; Moser, H; Naef, R; Nicklin, P; Sandham, D; Stringer, R; Turner, K; Watson, S; Zurini, M 8-Aryl xanthines potent inhibitors of phosphodiesterase 5. Bioorg Med Chem Lett12:2587-90 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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P04972/P11541/P16586/P22571/P23439/Q95142 |
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Name: | P04972/P11541/P16586/P22571/P23439/Q95142 |
Synonyms: | Phosphodiesterase 6 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 155381 |
Components: | This complex has 6 components. |
Component 1 |
Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
Synonyms: | CNRG_BOVIN | GMP-PDE gamma | PDE6G | PDEG |
Type: | PROTEIN |
Mol. Mass.: | 9674.16 |
Organism: | Bos taurus |
Description: | ChEMBL_104859 |
Residue: | 87 |
Sequence: | MNLEPPKAEIRSATRVMGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII
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Component 2 |
Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
Synonyms: | PDE V-C1 | PDE6C | PDE6C_BOVIN | PDEA2 | cGMP phosphodiesterase 6C |
Type: | PROTEIN |
Mol. Mass.: | 98783.85 |
Organism: | Bos taurus |
Description: | ChEMBL_104859 |
Residue: | 855 |
Sequence: | MGEISQETVEKYLEANPQFAKEYFNRKLQVEVPSGGAQAPASASFPGRTLAEEAALYLEL
LEVLLEEAGSVELAAHRALQRLAQLLQADRCSMFLCRARNGTPEVASKLLDVTPTSKFED
NLVVPDREAVFPLDVGIVGWVAHTKKTFNVPDVKKNSHFSDFMDKQTGYVTRNLLATPIV
MGKEVLAVFMAVNKVDASEFSKQDEEVFSKYLSFVSIILKLHHTNYLYNIESRRSQILMW
SANKVFEELTDVERQFHKALYTVRTYLNCERYSIGLLDMTKEKEFYDEWPVKLGEVEPYK
GPKTPDGREVIFYKIIDYILHGKEEIKVIPTPPMDHWTLISGLPTYVAENGFICNMLNAP
ADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEYDEHIAETL
TQFLGWSLLNTDTYEKMNKLENRKDIAQEMLMNHTKATPDEIKSILKFKEKLNIDVIEDC
EEKQLVTILKEDLPDPRTADLYEFRFRHLPITEHELIKCGLRLFFEINVVEKFKVPVEVL
TRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDID
HRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQYETVIHLF
EVAIIATDLALYFKKRTMFQKIVDACEKMETEEEAIKYVTIDPTKKEIIMAMMMTACDLS
AITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPKLQVGFIDFVCT
FVYKEFSRFHKEITPMLNGLQNNRVEWKSLADEYDEKMKVIEEMKKQEEGNTTEKAVEDS
GGGGDDKKSKTCLML
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Component 3 |
Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
Synonyms: | PDE6A | PDE6A_BOVIN | PDEA | Phosphodiesterase 6 | Phosphodiesterase 6A |
Type: | Enzyme |
Mol. Mass.: | 99320.22 |
Organism: | Bos taurus (Bovine) |
Description: | P11541 |
Residue: | 859 |
Sequence: | MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEESEI
IFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAELATRLFNVHKDAV
LEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTEEDEHFCDFVDTLTEYQTKNILAS
PIMNGKDVVAIIMVVNKVDGPHFTENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP
PYAGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM
NAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYHVKCDNEEIQTILKTREVYGKEPW
ECEEEELAEILQGELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACD
LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYETKMKGLEEEKQKQQAANQAAAGS
QHGGKQPGGGPASKSCCVQ
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Component 4 |
Name: | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
Synonyms: | CNCG_BOVIN | GMP-PDE gamma | PDE6H |
Type: | PROTEIN |
Mol. Mass.: | 9106.39 |
Organism: | Bos taurus |
Description: | ChEMBL_104859 |
Residue: | 83 |
Sequence: | MSDNTVLAPPTSNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDI
TVICPWEAFSHLELHELAQFGII
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Component 5 |
Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
Synonyms: | GMP-PDE delta | PDE6D | PDE6D_BOVIN |
Type: | PROTEIN |
Mol. Mass.: | 17388.28 |
Organism: | Bos taurus |
Description: | ChEMBL_104859 |
Residue: | 150 |
Sequence: | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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Component 6 |
Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
Synonyms: | GMP-PDE beta | PDE6B | PDE6B_BOVIN | PDEB |
Type: | PROTEIN |
Mol. Mass.: | 98307.54 |
Organism: | Bos taurus |
Description: | ChEMBL_104859 |
Residue: | 853 |
Sequence: | MSLSEGQVHRFLDQNPGFADQYFGRKLSPEDVANACEDGCPEGCTSFRELCQVEESAALF
ELVQDMQENVNMERVVFKILRRLCSILHADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVQDVMECPHFSSFADELTDYVTRNILATPI
MNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQAY
SGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNA
PADEMFNFQEGPLDDSGWIVKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDREEIQLILPTRERLGKEPADC
EEDELGKILKEVLPGPAKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEDQKKETTAKKVGTEICN
GGPAPRSSTCRIL
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BDBM50117715 |
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n/a |
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Name | BDBM50117715 |
Synonyms: | 3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-phenyl]-3,7-dihydro-purine-2,6-dione | CHEMBL87202 |
Type | Small organic molecule |
Emp. Form. | C24H34N6O5S |
Mol. Mass. | 518.629 |
SMILES | CCCOc1ccc(cc1-c1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1 |
Structure |
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