Reaction Details |
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Target | Cholesteryl ester transfer protein |
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Ligand | BDBM50118045 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_48930 (CHEMBL665925) |
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IC50 | 350±n/a nM |
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Citation | Durley, RC; Grapperhaus, ML; Hickory, BS; Massa, MA; Wang, JL; Spangler, DP; Mischke, DA; Parnas, BL; Fobian, YM; Rath, NP; Honda, DD; Zeng, M; Connolly, DT; Heuvelman, DM; Witherbee, BJ; Melton, MA; Glenn, KC; Krul, ES; Smith, ME; Sikorski, JA Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein. J Med Chem45:3891-904 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cholesteryl ester transfer protein |
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Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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BDBM50118045 |
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n/a |
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Name | BDBM50118045 |
Synonyms: | 1,1,1-Trifluoro-3-[(3-isopropoxy-benzyl)-(3-phenoxy-phenyl)-amino]-propan-2-ol | 1,1,1-trifluoro-3-((3-isopropoxybenzyl)(3-phenoxyphenyl)amino)propan-2-ol | CHEMBL339447 |
Type | Small organic molecule |
Emp. Form. | C25H26F3NO3 |
Mol. Mass. | 445.474 |
SMILES | CC(C)Oc1cccc(CN(CC(O)C(F)(F)F)c2cccc(Oc3ccccc3)c2)c1 |
Structure |
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