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Target5-hydroxytryptamine receptor 1A
LigandBDBM50118337
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1140 (CHEMBL616085)
Ki 1.9±n/a nM
Citation Orús, LPérez-Silanes, SOficialdegui, AMMartínez-Esparza, JDel Castillo, JCMourelle, MLanger, TGuccione, SDonzella, GKrovat, EMPoptodorov, KLasheras, BBallaz, SHervías, ITordera, RDel Río, JMonge, A Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. J Med Chem45:4128-39 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1A
Name:5-hydroxytryptamine receptor 1A
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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  Blast E-value cutoff:
BDBM50118337
n/a
NameBDBM50118337
Synonyms:1-(benzo[b]thiophen-3-yl)-3-(4-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)piperazin-1-yl)propan-1-ol | 1-Benzo[b]thiophen-3-yl-3-[4-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)-piperazin-1-yl]-propan-1-ol | CHEMBL337659
TypeSmall organic molecule
Emp. Form.C24H28N2O3S
Mol. Mass.424.556
SMILESOC(CCN1CCN(CC1)c1cccc2OCCCOc12)c1csc2ccccc12
Structure
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