| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50118470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105275 (CHEMBL718943) |
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| Ki | 0.045±n/a nM |
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| Citation |  Uchikawa, O; Fukatsu, K; Tokunoh, R; Kawada, M; Matsumoto, K; Imai, Y; Hinuma, S; Kato, K; Nishikawa, H; Hirai, K; Miyamoto, M; Ohkawa, S Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. J Med Chem45:4222-39 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50118470 |
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| n/a |
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| Name | BDBM50118470 |
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| Synonyms: | CHEMBL1218 | N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b | RAMELTEON | Rozerem |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21NO2 |
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| Mol. Mass. | 259.3434 |
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| SMILES | CCC(=O)NCC[C@@H]1CCc2ccc3OCCc3c12 |
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| Structure | 
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