| Reaction Details |
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 | Report a problem with these data |
| Target | Sorbitol dehydrogenase |
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| Ligand | BDBM50118708 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_223917 (CHEMBL846063) |
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| IC50 | 10±n/a nM |
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| Citation |  Mylari, BL; Oates, PJ; Zembrowski, WJ; Beebe, DA; Conn, EL; Coutcher, JB; O'Gorman, MT; Linhares, MC; Withbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem45:4398-401 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sorbitol dehydrogenase |
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| Name: | Sorbitol dehydrogenase |
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| Synonyms: | DHSO_RAT | Sdh1 | Sord |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38239.67 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_223914 |
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| Residue: | 357 |
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| Sequence: | MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDF
VVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFC
ATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCG
AGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL
GSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRY
CNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
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| BDBM50118708 |
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| n/a |
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| Name | BDBM50118708 |
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| Synonyms: | 1-{4-[2,6-Dimethyl-4-(4-phenyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-ethanol | CHEMBL136103 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N7O |
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| Mol. Mass. | 391.4695 |
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| SMILES | C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ncnc(n1)-c1ccccc1 |
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| Structure | 
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