Reaction Details |
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Target | Sorbitol dehydrogenase |
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Ligand | BDBM50118706 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_223917 (CHEMBL846063) |
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IC50 | 6±n/a nM |
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Citation | Mylari, BL; Oates, PJ; Zembrowski, WJ; Beebe, DA; Conn, EL; Coutcher, JB; O'Gorman, MT; Linhares, MC; Withbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem45:4398-401 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sorbitol dehydrogenase |
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Name: | Sorbitol dehydrogenase |
Synonyms: | DHSO_RAT | Sdh1 | Sord |
Type: | PROTEIN |
Mol. Mass.: | 38239.67 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_223914 |
Residue: | 357 |
Sequence: | MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDF
VVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFC
ATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCG
AGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL
GSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRY
CNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
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BDBM50118706 |
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n/a |
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Name | BDBM50118706 |
Synonyms: | (S)-1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | 1-(4-{2,6-Dimethyl-4-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | CHEMBL136900 |
Type | Small organic molecule |
Emp. Form. | C21H32N8O |
Mol. Mass. | 412.5318 |
SMILES | C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1ccnc(n1)N1CCN(C)CC1 |
Structure |
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