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TargetSorbitol dehydrogenase
LigandBDBM50118711
Substrate/Competitorn/a
Meas. Tech.ChEMBL_223917 (CHEMBL846063)
IC50 9±n/a nM
Citation Mylari, BLOates, PJZembrowski, WJBeebe, DAConn, ELCoutcher, JBO'Gorman, MTLinhares, MCWithbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem45:4398-401 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sorbitol dehydrogenase
Name:Sorbitol dehydrogenase
Synonyms:DHSO_RAT | Sdh1 | Sord
Type:PROTEIN
Mol. Mass.:38239.67
Organism:Rattus norvegicus
Description:ChEMBL_223914
Residue:357
Sequence:
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDF
VVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFC
ATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCG
AGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVL
GSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRY
CNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50118711
n/a
NameBDBM50118711
Synonyms:1-{4-[4-(4,6-Dimethyl-[1,3,5]triazin-2-yl)-2,6-dimethyl-piperazin-1-yl]-pyrimidin-2-yl}-ethanol | CHEMBL136680
TypeSmall organic molecule
Emp. Form.C17H25N7O
Mol. Mass.343.4267
SMILESC[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(C)n1
Structure
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