| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-8 |
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| Ligand | BDBM50119262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_46862 (CHEMBL659710) |
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| IC50 | 7.6±n/a nM |
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| Citation |  Linton, SD; Karanewsky, DS; Ternansky, RJ; Chen, N; Guo, X; Jahangiri, KG; Kalish, VJ; Meduna, SP; Robinson, ED; Ullman, BR; Wu, JC; Pham, B; Kodandapani, L; Smidt, R; Diaz, JL; Fritz, LC; von Krosigk, U; Roggo, S; Schmitz, A; Tomaselli, KJ Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett12:2973-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-8 |
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| Name: | Caspase-8 |
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| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 55373.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14790 |
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| Residue: | 479 |
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| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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| BDBM50119262 |
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| n/a |
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| Name | BDBM50119262 |
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| Synonyms: | 4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide | CHEMBL322631 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N3O5 |
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| Mol. Mass. | 413.4669 |
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| SMILES | CC(C)CC(NC(=O)CNc1cccc2ccccc12)C(=O)N[C@H]1CC(=O)OC1O |
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| Structure | 
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