| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-6 |
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| Ligand | BDBM50119267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_46699 (CHEMBL876967) |
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| IC50 | 3.5±n/a nM |
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| Citation |  Linton, SD; Karanewsky, DS; Ternansky, RJ; Chen, N; Guo, X; Jahangiri, KG; Kalish, VJ; Meduna, SP; Robinson, ED; Ullman, BR; Wu, JC; Pham, B; Kodandapani, L; Smidt, R; Diaz, JL; Fritz, LC; von Krosigk, U; Roggo, S; Schmitz, A; Tomaselli, KJ Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett12:2973-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Caspase-6 |
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| Name: | Caspase-6 |
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| Synonyms: | Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 33312.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55212 |
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| Residue: | 293 |
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| Sequence: | MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
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|
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| BDBM50119267 |
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| n/a |
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| Name | BDBM50119267 |
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| Synonyms: | 4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butylcarbamoyl]-4-(naphthalen-1-yloxy)-butyric acid | CHEMBL101545 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N2O8 |
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| Mol. Mass. | 486.5143 |
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| SMILES | CC(C)CC(NC(=O)[C@H](CCC(O)=O)Oc1cccc2ccccc12)C(=O)N[C@H]1CC(=O)OC1O |
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| Structure | 
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