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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM50119489
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52885 (CHEMBL665409)
Ki 4±n/a nM
Citation Haque, TSTadesse, SMarcinkeviciene, JRogers, MJSizemore, CKopcho, LMAmsler, KEcret, LDZhan, DLHobbs, FSlee, ATrainor, GLStern, AMCopeland, RACombs, AP Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. J Med Chem45:4669-78 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50119489
n/a
NameBDBM50119489
Synonyms:1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide] | CHEMBL341925
TypeSmall organic molecule
Emp. Form.C23H18ClN5O2
Mol. Mass.431.874
SMILESClc1ccc(cc1)-n1nc(cc1C(=O)Nc1ccccc1)C(=O)NCc1cccnc1
Structure
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