| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50119658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36921 (CHEMBL876759) |
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| Ki | 80±n/a nM |
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| Citation |  Le Bourdonnec, B; Cauvin, C; Meulon, E; Yous, S; Goossens, JF; Durant, F; Houssin, R; Hénichart, JP Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan. J Med Chem45:4794-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM50119658 |
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| n/a |
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| Name | BDBM50119658 |
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| Synonyms: | 7-Butyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-7,8-diaza-spiro[4.5]decane-6,9-dione | 7-Butyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-7,8-diaza-spiro[4.5]decane-6,9-dione | CHEMBL146275 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O2 |
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| Mol. Mass. | 458.5554 |
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| SMILES | CCCCN1N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C(=O)CC2(CCCC2)C1=O |
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| Structure | 
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